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Redesigning enzymes

Enzymes are proteins that regulate the rate of chemical reactions involved in biological processes. Researchers at the UAB Department of Biochemistry and Molecular Biology are currently studying strategies to artificially alter the structure of enzymes in order to modify their behaviour.

Enzimes

UAB's researchers have applied atomic force microscopy to study chromatin -DNA and histones- in its natural aqueous environment and have found that it is much more compact than previously thought. A fact that will have to be considered to understand the mechanism of DNA transcription during the cell cycle.

Cromatina

After being synthesized, the proteins fold themselves to acquire their function. Although this process, called oxidative folding, has been investigated extensively, some keys aspects have been neglected, like the thermodynamics or the computational prediction. UAB researchers disassembled this puzzle and its conclusions became a one single theory...

Claus moleculars del plegament oxidatiu