Signaling and New Therapeutic Targets (SINDIATER)
- Dr. Carlos Barcia
- Dr. Jose Ramón Bayascas
- Dr. Esther Dalfó
- Dr. Michael Edel
- Dr. Roser Masgrau and Dr. Enrique Claro
- Dr. Víctor Yuste and Dr. Marian Baltrons
- To establish experimental and therapeutic strategies to reduce neuronal vulnerability in Alzheimer’s and Parkinson’s disease
- To establish experimental and therapeutic strategies to increase gliobastoma vulnerability
- To develop new biological models to support and study objectives 1 and 2
- Study of neuronal Akt and lipid/Rac1 signalling pathways in neuronal vulnerability
- Characterization of lipid signalling and metabolism between astrocytes and neurons as new key element for neuronal survival
- Understanding of the process of microglial phagocytosis to avoid 1) the elimination of neurons and 2) to increase glioblastoma vulnerability
- Validation of the DFF40/CAD apoptotic pathway to increase glioblastoma cell death
- Development of drug discovery approaches and therapies for Alzheimer’s and Parkinson’s Diseases and to treat patients with glioblastoma based on the mentioned signalling pathways
- Oxidación de ácidos grasos en astrocitos: función en el cerebro y alteración en individuos APOE4. Ministerio de Ciencia e Innovación, Gobierno de España.
- Adaptative microglial response to antigens in Parkinson’s disease: understanding the phagocytic response in training and tolereance. Ministerio de Ciencia e Innovación, Gobierno de España.
- Assaig de l’inhibidor d’Akt MK-2206 pel tractament de la Malaltia d’Alzheimer. UAB.
- Recubrimientos multifuncionales bioinspirados para la captación y eliminación de virus en entornos hospitalarios (COVICAP). Ministerio de Ciencia e Innovación, Gobierno de España. Colaboración púbico-privada.
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Álvarez I, Tirado-Herranz A, Alvarez-Palomo B, Requena Osete J, Edel MJ. Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations. Cells 2023, 12(24), 2800; https://doi.org/10.3390/cells12242800
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Martínez-Escardó L, Alemany M, Sánchez-Osuna M, Sánchez-Chardi A, Roig-Martínez M, Suárez-García S, et al. Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells. Cancers (Basel). 2021 Nov 8;13(21):5579. 10.3390/cancers13215579
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Calls A, Torres-Espin A, Navarro X, Yuste VJ, Udina E, Bruna J. Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response. Neuro Oncol. 2021 Jan 30;23(1):88–99. 10.1093/neuonc/noaa151
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Cribaro GP, Saavedra-López E, Romarate L, Mitxitorena I, Díaz LR, Casanova PV, et al. Three-dimensional vascular microenvironment landscape in human glioblastoma. Acta Neuropathologica Communications. 2021 Feb 12;9(1):24. 10.1186/s40478-020-01115-0
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Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, García-Barrera T, et al. Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice. Mol Neurodegener. 2020 Jun 9;15(1):35. 10.1186/s13024-020-00382-8
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Coppa A, Guha S, Fourcade S, Parameswaran J, Ruiz M, Moser AB, et al. The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance: A worm model for adrenoleukodystrophy. Free Radic Biol Med. 2020 May 20;152:797–809. 10.1016/j.freeradbiomed.2020.01.177
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Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist. Journal of the American Chemical Society 2019 141 (18), 7628-7636. Available from: https://pubs.acs.org/doi/10.1021/jacs.9b03505
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Eraso-Pichot A, Brasó-Vives M, Golbano A, Menacho C, Claro E, Galea E, Masgrau Rx. Glia. 2018 https://onlinelibrary.wiley.com/doi/10.1002/glia.23330
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Díaz LR, Saavedra-López E, Romarate L, Mitxitorena I, Casanova PV, Cribaro GP, et al. Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma. JCI Insight [Internet]. 2018 Sep 20;3(18). Available from: https://insight.jci.org/articles/view/120757
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Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proceedings of the National Academy of Sciences. 2018 Oct 9;115(41):10481–6. 10.1073/pnas.1804198115
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