Biomedical research in Alzheimer's disease

Our research group studies the molecular and cellular mechanisms underlying memory loss and neuropsychiatric disorders in the human brain during biological and pathological aging. We want to know the molecular mechanisms involved in the different cellular vulnerability in the brain in the initial stages of Alzheimer's disease. For this purpose, we use state-of-the-art omics techniques - genomics, transcriptomics and proteomics - together with high-resolution microscopy in new models of Alzheimer's disease generated in our laboratory that allows us to study the transcriptome in specific cell populations. The combination of physiology and pathology techniques with systems biology approaches allows us to correlate transcriptomic and pathological changes in cell types and specific brain regions related to memory and emotions This information is enormously relevant for developing new diagnostic and therapeutic strategies in Alzheimer's disease.

Ref: 2021 SGR 00142