Neuroplasticity and Regeneration
Ref: 2021 SGR 00488
- Dr. Mireia Herrando
- Dr. Guillermo García-Alías
- Dr. Rubèn López
- Dr. Xavier Navarro
- Dr. Clara Penas
- Dr. Esther Udina
- Cellular and molecular mechanisms involved in degeneration of motoneurons in experimental models. Neuroprotective strategies based on gene and pharmacological therapy.
- Cell therapy by transplantation of mesenchymal stem cells and olfactory glia for the repair of spinal cord injuries and motoneuron degenerative diseases.
- Etiopathogenic role of lipid mediators and modulators of the neuroinflammatory response in neurodegeneration induced by central nervous system lesions.
- Activity-dependent therapies for enhancing axonal regeneration and functional recovery after peripheral nerve lesions.
- Physiopathological mechanisms in neuropathic pain induced by nerve and spinal cord lesions.
- Etiopathogenic mechanisms and potential neuroprotective treatments in peripheral neuropathies induced by diabetes and by antitumoral agents.
- Design and evaluation of neural interfaces for the development of neuroprostheses applied to neurorehabilitation.
- Neuromodulation for functional recovery in spinal cord injuries and degenerative processes.
- Project GA 899822, H2020 FET Open, European Commission, 2020-2024. “Ultrasound peripheral interface and in-vitro model of human somatosensory system and muscles for motor decoding and restoration of somatic sensations in amputees (SOMA)”. IP Xavier Navarro
- Proyecto PID2019-108496RA-I00, Ministerio de Ciencia, Innovación y Universidades; Retos Investigación, 2020-2023. “Terapia epigenética para promover la recuperación funcional después de una lesión de médula espinal (EPISCI)¨. IP Clara Penas
- Proyecto PID2020-120267RB-I00. Ministerio de Ciencia, Innovación; Retos Investigación, 2021-2023. Papel de la interleucina-38 en lesiones y enfermedades del sistema nervioso central. IP Rubèn López Vales
- Proyecto PDC2021-121791-I00, Ministerio de Ciencia e Innovación; Pruebas de Concepto 2021, 2021-2023. Neuroresolving therapeutics for spinal cord injury. IP Rubèn López Vales Proyecto PI2020/08-1
- Proyecto Intramural, CIBERNED, 2021-2023. CIBER-CALS: a CIBERned drug discovery network to test Calcium modulators as treatment for ALS. IP local: Xavier Navarro
- Proyecto PDC2021-121276-C33, Ministerio de Ciencia e Innovación; Pruebas de Concepto 2021, 2021-2023. Optimización de protocolos de actuación neuromórfica para un dispositivo de memoria accionado magnetoiónicamente. IP Carme Nogués; Miembro del Equipo Xavier Navarro
- Proyecto H2020-MSCA-IF-2020-CD300f; European Commission, 2021-2023. Unravelling the role of the immune receptor CD300f in spinal cord injury and metabolic reprogramming. IP Rubèn López Vales
- Proyecto PCI2021-122075-2A, FLAG–ERA JTC and Agencia Estatal de Investigación, 2022-2024. Functional stimulation system for rehabilitation of gait and driving neural plasticity after spinal cord injury using graphene-based nerve electrodes (RESCUEGRAPH). IP Xavier Navarro
- Grupo de la Red de Terapias Avanzadas (TERAV) RD21/0017/0008, Instituto de Salud Carlos III, 2022-2025. IP Miguel Chillón. Miembro del Equipo Ruben Lopez Vales
- PID2021-127626OB-I00 PID2021-127626OB-I00. Ministerio de Ciencia e Innovación, 2022-2025. Rejuvenating peripheral neurons to promote specific regeneration after peripheral nerve injuries in animal models. Competitive research. IP Esther Udina
- PID2021-126969OB-I00. Evalucion de la plasticidad de una red cortico-espinal, Ministerio de Ciencia e Innovación,, 2022-2024. IP Guillermo García-Alías
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Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response. Neuro Oncol. 2021 Jan 30;23(1):88-99.doi: 10.1093/neuonc/noaa151.
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Preferential regeneration and collateral dynamics of motor and sensory neurons after nerve injury in mice. Exp Neurol. 2022 Dec;358:114227.doi: 10.1016/j.expneurol.2022.114227. Epub 2022 Sep 13.
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Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep. Cells. 2022 Dec 16;11(24):4074.doi: 10.3390/cells11244074.
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Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis. Neurotherapeutics. 2020 Jul;17(3):1048-1060.doi: 10.1007/s13311-019-00811-7.
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Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2022 Feb 2;19(1):27.doi: 10.1186/s12974-022-02386-1.
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Extracellular and nuclear roles of IL-37 after spinal cord injury. Brain Behav Immun. 2021 Jan;91:194-201.doi: 10.1016/j.bbi.2020.09.026. Epub 2020 Sep 28.
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Sensory Involvement in Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2022 Dec 8;23(24):15521.doi: 10.3390/ijms232415521.
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Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice. Neurobiol Dis. 2020 Apr;137:104793.doi: 10.1016/j.nbd.2020.104793. Epub 2020 Feb 4.
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Correction to: BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury. J Neuroinflammation. 2022 Sep 19;19(1):230.doi: 10.1186/s12974-022-02590-z.
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Long-term rehabilitation reduces task error variability in cervical spinal cord contused rats. Exp Neurol. 2022 Feb;348:113928.doi: 10.1016/j.expneurol.2021.113928. Epub 2021 Nov 20
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