Neurobiology of stress and vulnerability to psychopathology
Ref: 2021 SGR 00158
- Dr. Antonio Armario
- Dr. Raül Andero (Anderolab)
- Dr. Roser Nadal (Humanlab website)
- Validation of animal models of stress
- Translation biomarkers of stress
- The study of the brain areas involved in processing stress
- The role of the hypothalamic-pituitary-adrenal axis in the impact of stress
- Understand sex and gender differences in the impact of stress in animals and humans
- Study how the molecular mechanisms and neural circuitry underlying fear memory in mice and humans are affected by stress
- Understand sex and gender differences in these fear memory mechanisms and circuits
- Transfer data to the clinic in order to find better treatments for stress-related disorders such as anxiety, depression, post-traumatic stress disorder (PTSD), panic disorder or specific phobias.
- Neurobiology of stress in animal models
- Translational Mechanisms of Fear Memory
- Neurobiology of stress in children
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Translational biomarkers of traumatic stress. ERA-NET NEURON / Instituto de Salud Carlos III / MICINN (2019-2023).
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Involvement of the gut microbiota-brain cross talk in the loss of eating. CaixaResearch Health (2022-2025).
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Biomarcador traslacional de la experiencia de estrés traumático. Becas Leonardo – BBVA a Investigadores y Creadores Culturales (2022).
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Tratamiento preventivo e identificación de biomarcadores de diagnóstico precoz para el trastorno de estrés postraumático en adolescentes. Fundación Alicia Koplowitz_Ayudas a la investigación en psiquiatría y neurociencias del niño y el adolescente (2022)
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SexoMemoria. Sex differences in fear memory. Retos Investigación_Proyectos I+D+i 2020. MICINN (2020-2023).
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Genomic, epigenetic and proteomic biomarkers in psychosis: a translational approach including high-risk individuals, patients with schizophrenia and animal models. ERANET NEURON (2020-2023).
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CIBERSAM (Centro de Investigación Biomédica en Red en Salud Mental), Instituto de Salud Carlos III, (2020-actualidad en curso).
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Aggressive behavior and conduct disorder: heterogeneity and development in children. Ministerio de Ciencia e Innovación. (2021-2024).
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What is different in the brain processing of traumatic stressors? Ministerio de Ciencia e Innovación. (2021-2024).
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Trets psicopàtics i prosocialitat a una mostra comunitària de nens i nenes: Un estudi longitudinal dels correlats biològics, emocionals i psicopatològics. Fundació La Marató de TV3. (2023-2026).
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Xarxa d’Innovació de Noves Tecnologies en Salut Mental (TECSAM), Ajuts per a xarxes d’R+D+I2020. Generalitat de Catalunya, (2023-2025).
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Neurobiología del estrés y la vulnerabilidad a la Psicopatología. Generalitat de Catalunya, GRC. (2023-2026).
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Red Temática Española de Investigación en Estrés (resolución provisional). Ministerio de Ciencia e Innovación. (2023-2025).
- Sanchís-Ollé M, Fuentes S, Úbeda-Contreras J, Lalanza JF, Ramos-Prats A, Armario A, et al. Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood. Sci Rep. 2019 Feb 28;9(1):3180.
- Wingo AP, Velasco ER, Florido A, Lori A, Choi DC, Jovanovic T, et al. Expression of the PPM1F Gene Is Regulated by Stress and Associated With Anxiety and Depression. Biol Psychiatry. 2018 Feb 1;83(3):284–95.
- Armario A, Labad J, Nadal R. Focusing attention on biological markers of acute stressor intensity: Empirical evidence and limitations. Neurosci Biobehav Rev. 2020 Apr;111:95–103.
- Flores Á, Fullana MÀ, Soriano-Mas C, Andero R. Lost in translation: how to upgrade fear memory research. Mol Psychiatry. 2018 Nov;23(11):2122–32.
- Sanchís-Ollé M, Sánchez-Benito L, Fuentes S, Gagliano H, Belda X, Molina P, et al. Male long-Evans rats: An outbred model of marked hypothalamic-pituitary-adrenal hyperactivity. Neurobiology of Stress. 2021 Nov 1;15:100355.
- Marín-Blasco I, Muñoz-Abellán C, Andero R, Nadal R, Armario A. Neuronal Activation After Prolonged Immobilization: Do the Same or Different Neurons Respond to a Novel Stressor? Cerebral Cortex. 2018 Apr 1;28(4):1233–44.
- Goldberg X, Espelt C, Porta-Casteràs D, Palao D, Nadal R, Armario A. Non-communicable diseases among women survivors of intimate partner violence: Critical review from a chronic stress framework. Neurosci Biobehav Rev. 2021 Sep;128:720–34.
- Velasco ER, Florido A, Flores Á, Senabre E, Gomez-Gomez A, Torres A, et al. PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus. Nat Commun. 2022 Jul 28;13(1):4374.
- Velasco ER, Florido A, Milad MR, Andero R. Sex differences in fear extinction. Neurosci Biobehav Rev. 2019 Aug;103:81–108.
- Florido A, Velasco ER, Soto-Faguás CM, Gomez-Gomez A, Perez-Caballero L, Molina P, et al. Sex differences in fear memory consolidation via Tac2 signaling in mice. Nat Commun. 2021 May 3;12(1):2496.
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