Brain diseases are among the main causes of life quality loss in our society. Cognitive and neurodegenerative diseases contribute to memory loss and neurosychiatric symptoms being the first cause of brain dissability in the elderly. Our main research interest focuses on investigating the cellular mechanisms underlying neuronal circuit dysfunction and pathological changes in memory disorders, particularly in Alzheimer’s disease. These studies are mandatory to develop novel therapeutic strategies for treating age-related dementias and neuropsychiatric disorders.
Our research interests are focused on investigating the neural circuits of memory and emotion, in order to unravel the cellular and molecular mechanisms involved in memory loss, emotional disturbances and neurodegeneration in age-related cognitive disorders, particularly in Alzheimer’s disease. By applying cell-specific transcriptomics, high-resolution imaging, chemogenetics and behavior, in novel transgenic and knockout mouse models of neurodegeneration and human samples, we investigate cell-specific transcriptional mechanisms underlying neuropsychiatric and cognitive disturbances in dementia. Our research projects provide knowledge of novel molecular targets and therapeutic strategies for early treatment of emotional and memory changes in age-related memory disorders.
