Seminar group "Statistical Modeling of Extreme Events and Health Risks" - Servei d'Estadística Aplicada
Title: Radiation dose estimation: the intersection of biology and statistics in biodosimetry
Speaker: Dorota Mlynarczyk - Departament de Matemàtiques, UAB
Day and hour: Thursday, April 25th, 2024 at 12:00 at Sala de seminari (C1/028) del Centre de Recerca Matemàtica (CRM) or online Teams
Place: Sala de seminaris (C1/028), Centre de Recerca Matemàtica (CRM), Facultat de Ciències, campus de la UAB. Also, this seminar will be available online (through Teams): link to online seminar
Duration: About 1 hour
Registration: Free registration. For capacity reasons will appreciate that you register: Register seminar form
Abstract:
Biological dosimetry relies on statistical methodologies to estimate radiation doses absorbed by individuals following accidental or therapeutic exposure. Central to this process is the assessment of various biomarkers' frequencies within blood cells, which serve as indicators of radiation-induced damage. Therefore, mathematical modelling in biodosimetry integrates biology, statistics, and advanced computational techniques to provide accurate and timely estimation of radiation dose in case of emergency. Complexity arises from the distinctive characteristics inherent to each biomarker. For instance, levels of gamma-H2AX change over post-radiation time, requiring three-dimensional models to capture dose-time dynamics. Partial body radiation, when only part of human body is exposed to radiation, leads to zero-inflated models. Incorporating these factors into mathematical models enhances the precision and reliability of dose estimation, crucial for optimizing treatment strategies following radiation exposure incidents.
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