NanoERT: nano-delivery platform for Enzyme Replacement Therapy in Parkinson´s and Gaucher's disease. Entitat finançadora: Caixa Impulse (CI24-20222). Entitats participants: UAB, VHIR, CIPF. Execució: 01/10/2024 - 30/09/2026. Investigadora responsable: Julia Lorenzo
NanoERT: nano-delivery platform for Enzyme Replacement Therapy in Parkinson’s and Gaucher’s disease. Entitat finançadora: AGAUR- Producte (2024 PROD 00073). Entitats participants: UAB, VHIR. Investigadora responsable: Julia Lorenzo.
Development of new nanotechnological based Enzyme Replacement Therapy for Parkinsons disease: restoration of lysosomal glucocerebrosidase activity through enzyme-polymer nanoconjugation of GBA. Entitat finançadora: Fundació BBVA. Entitats participants: VHIR/UAB/ICN. Execució: 01/05/2020 - 31/04/2023. Investigadora responsable: Marta Martínez Vicente
EVALUACION IN VITRO E IN VIVO DE NUEVOS NANOPORTADORES PARA ADMINISTRACION INTRANASAL EN EL TRATAMIENTO Y DIAGNOSTICO DE ENFERMEDADES CEREBRALES. (PID2021-127983OB-C22). Entitat finançadora: Ministerio de Ciencia e Innovación. Entitats participants: UAB. Execució: 01/10/2022 - 30/09//2025. Investigadora responsable: Julia Lorenzo Rivera
New Nanotechnological therapy for Parkinson’s disease: Nose to brain delivery of GBA-polymer nano conjugtes ref HR22-00602. Entitat finançadpra: Health Foundation La Caixa. Entitats participants: UAB/VHIR/CIPF. Execució: 01/11/2022 - 31/10/2025. Investigador responsable: Coordinador: M Martínez-Vicent (VHIR), PI: J Lorenzo (UAB), MJ Vicent (CIPF)
DEMOSTRACION DE LA EFICACIA DE LA REGENERACION TISULAR EN UN MODELO PRECLINICO DE HERIDAS. Ref: PDC2022-133261-C22. Entitat finançadora: Ministerio de Ciencia e Innovación. Entitats participants: UAB. Execució: 01/12/2022 - 30/11/2024. Investigadora responsable: Julia Lorenzo
N-TETRASCAN: Noves teràpies pel tractament i seguiment no invasiu de malalties cerebrals i cáncer (ref 2021SGR 00135). Entitat finançadora: Ajuts per donar suport a l'activitat científica dels grups de recerca de Catalunya (SGR-Cat 2021). AGAUR. Entitats participants: UAB. Execució: 01/01/2023 - 31/12/2025. Investigador responsable: Julia Lorenzo
Xarxa R+D+I en Tecnologies de la Salut (Xartec Salut) (ref: 2021 XARDI 00021). Entitat finançadora: AGAUR. Entitats participants: UAB; UPC, UB, IBEC, Hospital ClíBIB, BIB, Leitat. Execució: 01/01/2023 - 31/12/2025. Investigador responsable: Per la UAB Margarida Julià
Garcia L., Garcia-Pardo J., Tort O., Prior I., Brust M. Lorenzo J*. and Puntes V*. Trapping transmembrane cellular receptors inside the cell, avoiding receptor recycling and improving antibody therapy using gold nanoparticles. Nanoscale. 2017 May 11;9(18):6111-6121. doi: 10.1039/c7nr00947j.
Garcia-Guerrero MC, Garcia-Pardo J., Berenguer E, Fernandez-Alvarez R, Barfic GB, Lyons PJ, Aviles FX, Huber R., Lorenzo J* and Reverter D*. Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc Natl Acad Sci. 2018. Apr 24;115(17): E3932-E3939. doi: 10.1073/pnas.1803685115.
Suarez-Garcia S., Arias-Ramos N., Frias C., Candiota A., Arús C., Lorenzo, J.*; Ruiz-Molina D.; Novio, F. Dual T1/T2 Nanoscale Coordination Polymers as Novel Contrast Agents for MRI: a Preclinical Study for Brain Tumor. ACS Appl. Mater. Interfaces. 2018, 10, 45, 38819-38832. DOI: 10.1021/acsami.8b15594.
Marcelo G. A, Lodeiro C, Capelo J. L, Lorenzo J, Oliveira E. Magneto-fluorescent nanoparticles: from synthesis to application in Biosystems. Materials Science & Engineering C. 2020. 116: 10.1016/j.msec.2019.110104.
Marcelo GA., Montpeyó D., Ruiz-Molina D., Novio F., Lorenzo J.*, Oliveira E.*. Luminescent Silicon-based Nanocarrier for Drug Delivery in Colorectal Cancer Cells. Dyes and Pigents. 2020. 181: 108393. DOI: 10.1016/j.dyepig.2020.108393.
Djafari J, Fernández-Lodeiro J, Santos HM, Lorenzo J*, Rodriguez-Calado S, Bértolo E, Capelo-Martínez JL, Lodeiro C. Study and Preparation of multifunctional Poly(L-Lysine)@Hyaluronic acid nanopolyplexes for the effective delivery of tumor suppressive MiR-34a into triple negative breast cancer cells. Materials. 2020. 20(23): 5309. DOI: 10.3390/ma13235309.
García-Pardo J, Novio F, Nador F, Cavaliere I, Suárez-García S, Lope-Piedrafita S, Candiota AP, Romero-Gimenez J, Rodríguez-Galván B, Bové J, Vila M, Lorenzo J*, Ruiz-Molina D. Bioinspired Theranostic Coordination Polymer Nanoparticles for Intranasal Dopamine Replacement in Parkinson’s Disease. ACS Nano. 2021.15(5):8592-8609. doi: 10.1021/acsnano.1c00453.
Mao, X.; Calero-Pérez, P.; Montpeyó, D.; Bruna, J.; Yuste, V.J.; Candiota, A.P.; Lorenzo, J*; Novio, F.; Ruiz-Molina, D. Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy. Nanomaterials. 2022, 12, 1221. DOI: 10.3390/nano12071221.
Garcia-Pardo, J.; Montané, S.; Avilés, F.X.; Tanco, S.; Lorenzo, J*. Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation. Pharmaceutics 2022, 14, 2138. DOI:10.3390/pharmaceutics14102138.
Peña, Q., Simaan, A. J., Capdevila, M., Bayón, P., Palacios, O., Lorenzo, J*., & Iranzo, O. (2022). Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy. Frontiers in Pharmacology. 2022 Nov 15;13:1060827. Doi: 10.3389/fphar.2022.1060827. eCollection 2022.
Rodriguez-Calado S, Van Damme P, Avilés FX, Candiota AP, Tanco S, Lorenzo J*. Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly. Int J Mol Sci. 2023 Jan 9;24(2):1273. doi: 10.3390/ijms24021273.
Fonseca J, Cano-Sarabia M, Cortés P, Saldo J, Montpeyó D, Lorenzo J, Llagostera M, Imaz I, Maspoch D. Metal-Organic Framework-Based Antimicrobial Touch Surfaces to Prevent Cross-Contamination. Adv Mater. 2024:e2403813. Doi: 10.1002/adma.202403813.
Gómez-Herrera, R., Alfonso-Triguero, P., Mao, X., Mancebo-Aracil, J., Novio, F., Lorenzo, J*., Ruiz-Molina, D. Bioinspired neuromelanin-like Pt(IV) polymeric nanoparticles for cancer treatment. Nanotechnology Reviews. 2024.
Jiménez, R., Constantinescu, A., Yazir, M., Alfonso-Triguero, P., Pequerul, R., Parés, X., Pérez-Alea, M., Candiota, A. P., Farrés, J., Lorenzo, J*. Targeting retinaldehyde dehydrogenases in combined therapy against glioblastoma. Int J Mol Sci 2024. 25(21), 11512. Doi: 10.3390/ijms252111512.
